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Retatrutide
Lot PL-2701≥ 99.3% HPLCMetabolic

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Triple receptor agonist (GLP-1, GIP and glucagon receptor), research code LY3437943. A metabolic research peptide, studied in relation to glucose homeostasis and metabolic regulation in preclinical research.

Research areas

  • Glucose homeostasis research
  • Appetite and satiety regulation
  • Body composition studies
  • Cardiovascular metabolic studies
Storage−20 °C, dry and dark
FormLyophilised powder
Mol. weight4731.42 g/mol
LotPL-2701

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€49,95
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Triple receptor agonist (GLP-1, GIP and glucagon receptor), research code LY3437943. A metabolic research peptide, studied in relation to glucose homeostasis and metabolic regulation in preclinical research.

What is retatrutide? Mechanism of action

Retatrutide (development code LY3437943) is a synthetic peptide under clinical investigation. It differs from earlier generations of incretin analogues in targeting three receptors at once rather than one or two. That threefold action is why the literature refers to it as a triple agonist.

The three receptors are GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide) and the glucagon receptor. For comparison, semaglutide targets one receptor and tirzepatide two. Each receptor has its own role in glucose and energy regulation, and the published literature is largely concerned with how the three signalling routes interact.

Retatrutide holds no marketing authorisation anywhere. It is in clinical development and the published research spans phase 1 through phase 2. That distinction is not administrative: semaglutide and tirzepatide are authorised medicines in the European Union; retatrutide is not. We supply it solely as laboratory material for in-vitro research.

The peptide is supplied as a lyophilised (freeze-dried) powder. In that form it is stable for extended periods at low temperature, which is what makes it suitable for transport and storage before reconstitution in a laboratory.

Research areas

The areas below recur in the published literature on this molecule. They are directions of research, not applications — no statement is made about efficacy or suitability for any use.

  • Glucose homeostasis research
  • Appetite and satiety regulation
  • Body composition studies
  • Cardiovascular metabolic studies

Buying Retatrutide for research

Retatrutide is only as useful as research material as the documentation that comes with it. This is what we record per batch:

  • Every batch is analysed by HPLC. The purity figure and its lot number appear on this page and on the label.
  • The lot number on the vial matches the certificate of analysis, so the measurement traces back to the vial you receive.
  • Supplied as a lyophilised powder rather than a solution — the form that best survives transport and storage.
  • For analytical and preclinical laboratory research only. Not for human or animal consumption.

Reconstitution and storage

Lyophilised and unopened, the peptide is kept cool, dry and dark. Brief exposure to room temperature in transit is normal for the powder, and is precisely why it ships in this form.

The literature generally uses bacteriostatic water for reconstitution. Once reconstituted the solution has a limited shelf life and belongs in refrigerated storage. Exact conditions vary by protocol; we prescribe none.

Specifications

Storage−20 °C, dry and dark
FormLyophilised powder
Molecular weight4731.42 g/mol
Purity≥ 99.3% HPLC
LotPL-2701

Scientific sources

The publications below are the primary literature on this molecule. They are listed as a pointer to published research and are not a claim about this product.

  1. 1.Coskun T, et al. (2022). LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical trials. Cell Metabolism. PubMed 35985340
  2. 2.Urva S, et al. (2022). LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial. The Lancet. PubMed 36354040
  3. 3.Jastreboff AM, et al. (2023). Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. New England Journal of Medicine. PubMed 37366315
  4. 4.Sanyal AJ, et al. (2024). Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial. Nature Medicine. PubMed 38858523

Frequently asked questions

What does Retatrutide cost?
Retatrutide comes in several strengths, from € 49,95 for 5 mg to € 229,00 for 40 mg. Pick the strength at the top of this page and the price appears immediately. Ordering multiple vials applies a volume discount automatically.
Which strengths of Retatrutide are available?
4 strengths are in stock: 5 mg, 10 mg, 20 mg, 40 mg. Larger vials cost less per milligram; the price per mg is shown with each option.
Can I order Retatrutide in the Netherlands?
Yes. We ship from the Netherlands, discreetly and neutrally packaged, with track and trace. Within the Netherlands and Belgium delivery normally takes 1–2 working days after processing, elsewhere in the EU 2–5 working days. Payment is by iDEAL and shipping is free from €75.
Do I get a certificate of analysis with Retatrutide?
Yes. The current lot is PL-2701 with a measured purity of ≥ 99.3% HPLC. The lot number on the vial matches the certificate of analysis, so the measurement traces back to the vial you receive.
How do I store Retatrutide?
Unopened, Retatrutide is kept at −20 °C, dry and dark. It ships as Lyophilised powder; in that form it withstands transport. Once reconstituted the solution has a limited shelf life and belongs in refrigerated storage.
What is Retatrutide intended for?
In-vitro laboratory research only. Retatrutide is not intended for human or animal consumption, not for diagnostic use, and not for any therapeutic application. We provide no dosing and no administration guidance.
Retatrutide

Retatrutide

5 mg · €49,95

Buy Retatrutide | CoA & ≥99% purity | HEALTHYPEPTIDES