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For laboratory research only · not for human consumption
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MOTS-c
Lot PL-2703≥ 99.0% HPLCLongevity

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Mitochondrial-derived peptide of 16 amino acids encoded by the 12S rRNA gene in mitochondrial DNA. Studied in relation to cellular energy homeostasis, insulin sensitivity and metabolic regulation.

Research areas

  • Mitochondriale functie
  • Insuline-gevoeligheid studies
  • Metabole regulatie
  • Trainingsadaptatie onderzoek
Storage−20 °C, dry and dark
FormLyophilised powder
Mol. weight2174.50 g/mol
LotPL-2703
Reconstituting and storing: fridge or freezer?

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€34,95
Shipped in 1–2 business daysCoA per batch

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Mitochondrial-derived peptide of 16 amino acids encoded by the 12S rRNA gene in mitochondrial DNA. Studied in relation to cellular energy homeostasis, insulin sensitivity and metabolic regulation.

What is MOTS-c? Mechanism of action

MOTS-c is a sixteen-amino-acid peptide encoded not by nuclear DNA but by the mitochondrial genome — specifically by a reading frame within the 12S rRNA gene. That places it in a small group of molecules known as mitochondrial-derived peptides.

That origin is why the molecule recurs in metabolic research. The original 2015 paper described how MOTS-c acts on the folate cycle and thereby on AMPK, an enzyme that functions inside the cell as a sensor of energy status. Research focuses on glucose handling, insulin sensitivity and on communication between mitochondria and the nucleus.

Published work is predominantly preclinical. MOTS-c holds no marketing authorisation as a medicine anywhere.

We supply it as a lyophilised powder, solely as laboratory material for in-vitro research.

Research areas

The areas below recur in the published literature on this peptide. They are directions of research, not applications — no statement is made about efficacy or suitability for any use.

  • Mitochondriale functie
  • Insuline-gevoeligheid studies
  • Metabole regulatie
  • Trainingsadaptatie onderzoek

Buying MOTS-c for research

MOTS-c is only as useful as research material as the documentation that comes with it. This is what we record per batch:

  • Every batch is analysed by HPLC. The purity figure and its lot number appear on this page and on the label.
  • The lot number on the vial matches the certificate of analysis, so the measurement traces back to the vial you receive.
  • Supplied as a lyophilised powder rather than a solution — the form that best survives transport and storage.
  • For analytical and preclinical laboratory research only. Not for human or animal consumption.

Reconstitution and storage

Lyophilised and unopened, the peptide is kept cool, dry and dark. Brief exposure to room temperature in transit is normal for the powder, and is precisely why it ships in this form.

The literature generally uses bacteriostatic water for reconstitution. Once reconstituted the solution has a limited shelf life and belongs in refrigerated storage. Exact conditions vary by protocol; we prescribe none.

Specifications

Storage−20 °C, dry and dark
FormLyophilised powder
Molecular weight2174.50 g/mol
Purity≥ 99.0% HPLC
LotPL-2703

Scientific sources

The publications below are the primary literature on this molecule. They are listed as a pointer to published research and are not a claim about this product.

  1. 1.Lee C, et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism. PubMed 25738459
  2. 2.Zheng Y, Wei Z, Wang T. (2023). MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Frontiers in Endocrinology. PubMed 36761202

Frequently asked questions

What does MOTS-c cost?
MOTS-c costs € 49,95 for 10 mg. Ordering multiple vials applies a volume discount automatically.
Can I order MOTS-c in the Netherlands?
Yes. We ship from the Netherlands, discreetly and neutrally packaged, with track and trace. Within the Netherlands and Belgium delivery normally takes 1–2 working days after processing, elsewhere in the EU 2–5 working days. Payment is by iDEAL and shipping is free from €75.
Do I get a certificate of analysis with MOTS-c?
Yes. The current lot is PL-2703 with a measured purity of ≥ 99.0% HPLC. The lot number on the vial matches the certificate of analysis, so the measurement traces back to the vial you receive.
How do I store MOTS-c?
Unopened, MOTS-c is kept at −20 °C, dry and dark. It ships as Lyophilised powder; in that form it withstands transport. Once reconstituted the solution has a limited shelf life and belongs in refrigerated storage.
What is MOTS-c intended for?
In-vitro laboratory research only. MOTS-c is not intended for human or animal consumption, not for diagnostic use, and not for any therapeutic application. We provide no dosing and no administration guidance.
Reconstituting and storing: fridge or freezer?
MOTS-c

MOTS-c

5 mg · €34,95

Buy MOTS-c | CoA & ≥99% purity | HEALTHYPEPTIDES