HEALTHYPEPTIDESPrecision · Purity · Research
KPV (lysine-proline-valine) is a synthetic tripeptide corresponding to the C-terminal sequence (positions 11–13) of alpha-melanocyte-stimulating hormone (α-MSH). In preclinical models KPV inhibits the NF-κB signalling pathway by stabilising IκB-alpha, suppressing expression of pro-inflammatory mediators such as TNF-α, IL-1β and IL-6. This product is intended exclusively for scientific laboratory research and is not intended for human use.
Research areas
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10 stuks · €5,00/pak
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KPV (lysine-proline-valine) is a synthetic tripeptide corresponding to the C-terminal sequence (positions 11–13) of alpha-melanocyte-stimulating hormone (α-MSH). In preclinical models KPV inhibits the NF-κB signalling pathway by stabilising IκB-alpha, suppressing expression of pro-inflammatory mediators such as TNF-α, IL-1β and IL-6. This product is intended exclusively for scientific laboratory research and is not intended for human use.
KPV is a tripeptide of lysine, proline and valine. It is the C-terminal fragment of α-MSH (alpha-melanocyte-stimulating hormone), the endogenous hormone whose final three amino acids it reproduces.
What makes KPV interesting in the literature is that it appears to retain the anti-inflammatory signalling of α-MSH without the pigmentation effect of the full hormone: the melanocortin receptors that drive pigmentation are not engaged by the fragment in the same way. Research concentrates on intracellular inflammatory pathways, NF-κB in particular.
Published work is almost entirely preclinical — cell culture and animal models, including models of intestinal inflammation and dermatological research. KPV holds no marketing authorisation as a medicine anywhere.
We supply it as a lyophilised powder, solely as laboratory material for in-vitro research.
The areas below recur in the published literature on this peptide. They are directions of research, not applications — no statement is made about efficacy or suitability for any use.
KPV is only as useful as research material as the documentation that comes with it. This is what we record per batch:
Lyophilised and unopened, the peptide is kept cool, dry and dark. Brief exposure to room temperature in transit is normal for the powder, and is precisely why it ships in this form.
The literature generally uses bacteriostatic water for reconstitution. Once reconstituted the solution has a limited shelf life and belongs in refrigerated storage. Exact conditions vary by protocol; we prescribe none.
The publications below are the primary literature on this molecule. They are listed as a pointer to published research and are not a claim about this product.
KPV
10 mg · €54,95
